Physical characteristics and non-keplerian orbital motion of "propeller" moons embedded in Saturn's rings

We report the discovery of several large "propeller" moons in the outer part of Saturn's A ring, objects large enough to be followed over the 5-year duration of the Cassini mission. These are the first objects ever discovered that can be tracked as individual moons, but do not orbit in empty space. We infer sizes up to 1--2 km for the unseen moonlets at the center of the propeller-shaped structures, though many structural and photometric properties of propeller structures remain unclear. Finally, we demonstrate that some propellers undergo sustained non-keplerian orbit motion. (Note: This arXiv version of the paper contains supplementary tables that were left out of the ApJL version due to lack of space).Comment: 9 pages, 4 figures; Published in ApJ

METTL13 methylation of eEF1A increases translational output to promote tumorigenesis

Increased protein synthesis plays an etiologic role in diverse cancers. Here, we demonstrate that METTL13 (methyltransferase-like 13) dimethylation of eEF1A (eukaryotic elongation factor 1A) lysine 55 (eEF1AK55me2) is utilized by Ras-driven cancers to increase translational output and promote tumorigenesis in vivo. METTL13-catalyzed eEF1A methylation increases eEF1A's intrinsic GTPase activity in vitro and protein production in cells. METTL13 and eEF1AK55me2 levels are upregulated in cancer and negatively correlate with pancreatic and lung cancer patient survival. METTL13 deletion and eEF1AK55me2 loss dramatically reduce Ras-driven neoplastic growth in mouse models and in patient-derived xenografts (PDXs) from primary pancreatic and lung tumors. Finally, METTL13 depletion renders PDX tumors hypersensitive to drugs that target growth-signaling pathways. Together, our work uncovers a mechanism by which lethal cancers become dependent on the METTL13-eEF1AK55me2 axis to meet their elevated protein synthesis requirement and suggests that METTL13 inhibition may constitute a targetable vulnerability of tumors driven by aberrant Ras signaling.We thank Pal Falnes, Jerry Pelletier, and Julien Sage for helpful discussion, Lauren Brown and William Devine for SDS-1-021, and members of the Gozani and Mazur laboratories for critical reading of the manuscript. This work was supported in part by grants from the NIH to S.M.C. (K99CA190803), M.P.K. (5K08CA218690-02), J.A.P. (R35GM118173), M.C.B. (1DP2HD084069-01), J.S. (1R35GM119721), I.T. (R01CA202021), P.K.M. (R00CA197816, P50CA070907, and P30CA016672), and O.G. (R01GM079641). J.E.E. received support from Stanford ChEM-H, and A.M. was supported by the MD Anderson Moonshot Program. I.T. is a Junior 2 Research Scholar of the Fonds de Recherche du Quebec - Sante (FRQ-S). P.K.M. is supported by the Neuroendocrine Tumor Research Foundation and American Association for Cancer Research and is the Andrew Sabin Family Foundation Scientist and CPRIT scholar (RR160078). S.H. is supported by a Deutsche Forschungsgemeinschaft Postdoctoral Fellowship. J.W.F. is supported by 5T32GM007276. (K99CA190803 - NIH; 5K08CA218690-02 - NIH; R35GM118173 - NIH; 1DP2HD084069-01 - NIH; 1R35GM119721 - NIH; R01CA202021 - NIH; R00CA197816 - NIH; P50CA070907 - NIH; P30CA016672 - NIH; R01GM079641 - NIH; Stanford ChEM-H; MD Anderson Moonshot Program; Neuroendocrine Tumor Research Foundation; American Association for Cancer Research; Deutsche Forschungsgemeinschaft Postdoctoral Fellowship; 5T32GM007276)Supporting documentationAccepted manuscrip

Sequential induction of auxin efflux and influx carriers regulates lateral root emergence

Peer reviewe

Optimising age adjustment of trichiasis prevalence estimates using data from 162 standardised surveys from seven regions of Ethiopia.

PURPOSE: The prevalence of trichiasis is higher in females and increases markedly with age. Surveys carried out in the daytime, particularly in developing countries, are prone to find older individuals and females at home at the time of the survey. Population-level trichiasis estimates should adjust sample proportions to reflect the demographic breakdown of the population, although the most accurate method of doing this is unclear. METHODS: Having obtained data from 162 surveys carried out in Ethiopia as part of the Global Trachoma Mapping Project from 2012 to 2015, we used internal validation with both Brier and Logarithmic forecast scoring to test stratification models to identify those models with the highest predictive accuracy. Selection of partitions was undertaken by both simple random sampling (SRS) and cluster sampling (CS) over 8192 selections. RESULTS: A total of 4529 (1.9%) cases of trichiasis were identified from 241,139 individuals aged ≥15 years from a total of 4210 kebeles and 122,090 households visited. Overall, the binning method using 5-year bands from age 15 to 69 years, with coarser binning in 20-year age-bands above this age, provided the best predictive accuracy, in both SRS and CS methodologies and for both the Brier and Logarithmic scoring rules. CONCLUSION: The greatest predictive accuracy for trichiasis estimates was found by adjusting for sex and in 5-year age-bands from the age of 15 to 69 years and in 20-year age-bands in those aged 70 years and greater. Trichiasis surveys attempting to make population-level inferences should use this method to optimise surgery backlog estimates

Dynamics of Saturn's South Polar Vortex

The camera onboard the Cassini spacecraft has allowed us to observe many of Saturn's cloud features. We present observations of Saturn's south polar vortex (SPV) showing that it shares some properties with terrestrial hurricanes: cyclonic circulation, warm central region (the eye) surrounded by a ring of high clouds (the eye wall), and convective clouds outside the eye. The polar location and the absence of an ocean are major differences. It also shares properties with the polar vortices on Venus, such as polar location, cyclonic circulation, warm center, and long lifetime, but the Venus vortices have cold collars and are not associated with convective clouds. The SPV's combination of properties is unique among vortices in the solar system

Lightning on Jupiter observed in the H_α line by the Cassini imaging science subsystem

Night side images of Jupiter taken by the Cassini Imaging Science Subsystem (ISS) camera with the H_α filter reveal four lightning clusters; two of them are repeated observations of the same storm. All of these flashes are associated with storm clouds seen a few hours earlier on the day side of Jupiter. Some of the clouds associated with lightning do not extend to the upper troposphere. The repeated lightning observations taken 20 hr apart show that storm clouds, whose mean lifetime is ∼4 days, are electrically active during a large fraction of their lifetime. The optical power of the lightning detected with the H_α filter compared to the clear-filter power of Galileo lightning may indicate that the H_α line in the lightning spectrum is about ten times weaker than expected, consistent with a flat spectrum having no prominent H_α line. This may suggest that lightning is generated in atmospheric layers deeper than 5 bars. This, in turn, may suggest that the water abundance of the jovian interior is more than 1 × solar. Averaged over many flashes, the most powerful Cassini lightning storm emits 0.8×10^9 W in the H_α line, which implies 4×10^(10) W of broadband optical power. This is 10 times more powerful than the most intense jovian lightning observed before by Voyager 2

Lightning storms on Saturn observed by Cassini ISS and RPWS during 2004–2006

We report on Cassini Imaging Science Subsystem (ISS) data correlated with Radio and Plasma Wave Science (RPWS) observations, which indicate lightning on Saturn. A rare bright cloud erupt at ∼35° South planetocentric latitude when radio emissions (Saturn Electrostatic Discharges, or SEDs) occur. The cloud consisting of few consecutive eruptions typically lasts for several weeks, and then both the cloud and the SEDs disappear. They may reappear again after several months or may stay inactive for a year. Possibly, all the clouds are produced by the same atmospheric disturbance which drifts West at 0.45 °/day. As of March 2007, four such correlated visible and radio storms have been observed since Cassini Saturn Orbit Insertion (July 2004). In all four cases the SEDs are periodic with roughly Saturn's rotation rate (h^(10)m^(39)), and show correlated phase relative to the times when the clouds are seen on the spacecraft-facing side of the planet, as had been shown for the 2004 storms in [Porco, C.C., and 34 colleagues, 2005. Science 307, 1243–1247]. The 2000-km-scale storm clouds erupt to unusually high altitudes and then slowly fade at high altitudes and spread at low altitudes. The onset time of individual eruptions is less than a day during which time the SEDs reach their maximum rates. This suggests vigorous atmospheric updrafts accompanied by strong precipitation and lightning. Unlike lightning on Earth and Jupiter, where considerable lightning activity is known to exist, only one latitude on Saturn has produced lightning strong enough to be detected during the two and a half years of Cassini observations. This may partly be a detection issue

Saturn's south polar vortex compared to other large vortices in the solar system

Observations made by the Imaging Science Subsystem (ISS), Visible and Infrared Mapping Spectrometer (VIMS) and the long-wavelength Composite Infrared Spectrometer (CIRS) aboard the Cassini spacecraft reveal that the large, long-lived cyclonic vortex at Saturn's south pole has a 4200-km-diameter cloud-free nearly circular region. This region has a 4 K warm core extending from the troposphere into the stratosphere, concentric cloud walls extending 20–70 km above the internal clouds, and numerous external clouds whose anticyclonic vorticity suggests a convective origin. The rotation speeds of the vortex reach 150 ± 20 ms^-1 . The Saturn polar vortex has features in common with terrestrial hurricanes and with the Venus polar vortex. Neptune and other giant planets may also have strong polar vortices